Team news: Ashley Westwood was stretchered off with a serious ankle injury as Burnley held West Ham to a hard-fought draw at the weekend.
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Club captain Ben Mee, Erik Pieters (both knee) and Johann Berg Gudmundsson (calf) are also sidelined and set to be ruled out for the rest of April.
Southampton will travel to Turf Moor with plenty of “options”, manager Ralph Hasenhüttl advocated ahead of the rearranged tie. Following victory over Arsenal last time out, Saints once again have a full squad of players to select from.